Effects of Donor and Recipient Genetic Expression on Heart, Lung, Liver, or Kidney Transplant Survival

Activity of genes in donor tissues that are involved in inflammation are thought to be involved with early organ dysfunction, increased immune responses in transplant recipients, and organ rejection. The purpose of this study is to determine the relationship between genetic expression in donor and recipient tissue with transplant survival. Participants in this study will have received heart, lung, liver, or kidney transplants.

Inclusion Criteria for all participants: * Received single lung, heart, kidney, or liver transplant * Specimens of donor tissues have been collected * Parent or guardian willing to provide informed consent, if applicable Inclusion Criteria for Kidney or Liver Transplant Participants: * 70 years old or younger Inclusion Criteria for Heart or Lung Transplant Participants: * Between 16 and 70 years old Exclusion Criteria for All Participants: * Previous solid organ transplant * Need for combined organ transplant * HIV or hepatitis C virus infection * Recipient of an organ from a hepatitis C virus-infected donor * Clinical evidence of systemic bacterial infection in the recipient at the time of transplantation * Living donor transplant recipient of either a kidney, liver, or lung