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Terminated
NCT00547703
Effect of Nortriptyline on Abdominal Pain/Discomfort and Quality of Life in Patients With Nonulcer Dyspepsia
Conditions: Non Ulcer Dyspepsia
Sex: All
Ages: 18 Years – 65 Years
Healthy volunteers: No
Phase: NA
Enrollment: 5
Sponsor: The Cleveland Clinic
Location: Cleveland Clinic Florida Weston Florida
Summary
The purpose of this study is to determine if use of Nortriptyline will improve symptoms and quality of life in patients who have nonulcer dyspepsia.
Eligibility Criteria
Inclusion Criteria:
* Men and Women
* Ages 18-65
* Meet Rome III criteria for functional dyspepsia
* Endoscopy within 1 year
Exclusion Criteria:
* Allergic reaction or history of adverse events with Nortriptyline or tricyclic antidepressants
* Organic cause found on physical examination
* Organic cause found on lab work: Complete Blood Count, Comprehensive Metabolic Panel, Thyroid stimulating hormone, Tissue transglutaminase Immunoglobulin A
* Predominantly Gastroesophageal reflux symptoms
* Current Helicobacter pylori infection
* History of Peptic ulcer disease
* Non steroidal antiinflammatory use use \> 2x/wk
* Pregnant or planning pregnancy
* History of major depression
* Abdominal surgery in the last year
Source: ClinicalTrials.gov (NCT00547703). StuddyBuddy aggregates publicly available trial information.
