Vancomycin and Daptomycin Plus Cefazolin for Preoperative Vascular Surgery Prophylaxis

This study prospectively selects the patients to examine the effectiveness of the investigators' current standard of prophylaxis prior to vascular surgery and to compare the effectiveness of vancomycin and daptomycin plus cefazolin in reducing infections in vascular surgical patients.

Inclusion Criteria: * Patients greater than 18 years of age undergoing vascular surgery including carotid procedures and a vascular access procedure (Fistula or Graft). Exclusion Criteria: * Patients with an allergy to daptomycin or vancomycin. * Patients with chronic wounds. * Prior colonization of MRSA. * Increased MRSA rate facility wide. * Continuous inpatient stay \>27 hrs prior to surgical procedure. * Patients with active infection requiring antibiotics preoperatively. * Patients with a history of MRSA colonization or infection, HIV, admission for \>3 months in an acute care center or long-term care center, penicillin allergy or penicillin allergy and on dialysis. * Dialysis patients.