MIRNA Profiling of Breast Cancer in Patients Undergoing Neoadjuvant or Adjuvant Treatment for Locally Advanced & Inflammatory Breast Cancer

Conditions: Breast Cancer

Sex: Female

Ages: 18 Years – N/A

Healthy volunteers: No

Enrollment: 199

Sponsor: City of Hope Medical Center

Location: City of Hope Duarte California

Summary

MicroRNAs (MiRNAs) regulate the translation of RNAs and are implicated in cell proliferation and renewal both under physiologically normal as well as in malignant conditions. Dysregulation of specific miRNAs may be associated with either gaining oncogenic or loosing tumor suppressing functions. MiRNA dysregulation has been implicated in breast cancer tumorigenic (stem cell) and non-tumorigenic development. Therefore, miRNA profiling of treatment naïve and treatment-exposed breast tumors and sequential samples of blood/serum will allow for identification of miRNA markers of prognosis and as indicators and potential targets for personalized therapies. In this proposal, specimens from patients treated in the clinical breast cancer program on already existing protocols (IRB 05091 and 05015) will be characterized by Dr. Rossi's laboratory and collaborators, and the information gained will be applied to develop specific therapies.

Eligibility Criteria

Inclusion Criteria: * Female, * Breast Cancer * \> 18 years, * regardless of histology, treatment phase, or stage Exclusion Criteria: \-

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View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT01231386). StuddyBuddy aggregates publicly available trial information.