Evaluation and Diagnosis of Potential Research Subjects With Traumatic Brain Injury

Background: \- The Center for Neuroscience and Regenerative Medicine is working to improve physicians' understanding of brain injury. More information is needed on traumatic brain injury (TBI), especially how well a person recovers from TBI and how the brain changes over time in people with TBI. To conduct this research, the center is sponsoring a number of research studies on TBI and is interested in evaluating individuals with TBI or post-concussive syndrome to determine if they might be eligible for future studies. Objectives: \- To develop a pool of individuals with traumatic brain injury and post-concussive syndrome for future research studies. Eligibility: \- Individuals at least 18 years of age who have symptoms of or have been diagnosed with traumatic brain injury or post-concussive syndrome and are willing to participate in future studies. Design: * Participants will be screened with an initial telephone interview, and will be asked to come to the National Institutes of Health for an in-person screening visit. * At the screening visit, participants will provide a medical history, have a physical examination and complete a study questionnaire on their TBI and its symptoms, including how the injury occurred, when it occurred, and any previous brain-related injuries. * Subjects may also return for a second visit at the NIH CC if eligible. * Each visit may involve blood samples, an MRI scan, and a series of tests to evaluate brain function. * Participants will also provide contact information to enable researchers to contact them for future studies.

* INCLUSION CRITERIA: To be included, participants must meet all of the following: * Age greater than or equal to 18 years of age * Report having symptoms or diagnosis of concussion, TBI, post concussional syndrome, or post concussional disorder. * Are able to provide informed consent or, have a legally authorized representative (LAR) provide consent. * Are willing to have their contact information and data shared and stored by the CNRM for referral to current and future CNRM studies EXCLUSION CRITERIA: -Are unwilling or unable to cooperate with the study procedures