Enhancing the Anabolic Effect of Perioperative Nutrition With Insulin While Maintaining Normoglycemia

Sex: All

Ages: 18 Years – N/A

Healthy volunteers: No

Phase: PHASE4

Sponsor: McGill University Health Centre/Research Institute of the McGill University Health Centre

Location: McGill University Health Centre (MUHC) - Royal Victoria Hospital Montreal Quebec

Summary

The purpose of this study is to find out whether adding insulin after current colorectal cancer surgery promotes making and keeping proteins in the body, and to find out whether or not this effect can be further increased by increasing the amount of protein given.

Eligibility Criteria

Inclusion Criteria: * American Society of Anesthesiologists class\18 years * colorectal surgery for non-metastatic colorectal adenocarcinoma including right and left hemicolectomy, transverse, subtotal and total colectomy sigmoid and low anterior resection * ability to give informed consent Exclusion Criteria: * BMI\>30 Kg/meter squared * confirmed diagnosis of diabetes mellitus or a HbA1c\>6.0% * significant cardiorespiratory, hepatic, renal and neurological disease * musculoskeletal or neuromuscular disease * ingestion of drugs known to affect protein, glucose and lipid metabolism (e.g. steroids) * severe anemia (hemoglobin\

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View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT02032953). StuddyBuddy aggregates publicly available trial information.