Personalized Medicine Decision-Making in a Virtual Clinical Setting

Background: -How people respond to drugs depends in part on their genes. For some drugs, doctors can use an individuals genetic background to help in dosing the drug. Researchers want to know how doctors incorporate personalized or genomic medicine into clinical practice. Objective: -To study how physicians make personalized treatment decisions Eligibility: -Healthy adult primary care physicians who are internal (or family) medicine residents. Design: * Participants will complete a screening form. * Participants will put on a headset, called a head-mounted display, showing a virtual reality environment. * The environment will contain an exam room and the virtual patient. * After interacting with the virtual patient, participants will complete a series of survey measures. * Participation will last for about 60 minutes. The virtual patient interaction and follow-up questions will be audio taped.

* INCLUSION CRITERIA: * All physicians will be healthy adult volunteers who are medical residents in the internal medicine specialty. EXCLUSION CRITERIA: 1. persons with seizure or vestibular disorders; 2. persons who are highly prone to motion sickness; 3. those without normal or normal to corrected vision or hearing; 4. all current and past employees and contractors of NHGRI; and 5. persons who have received information about the study purpose or procedure from a past participant. NHGRI employees are excluded for this protocol because they are likely to have specialized genomic knowledge and may think differently about genomics in the clinical interaction.