The Effect of Influenza Vaccination on the Systemic Inflammatory Response and Myocardial Protection in Patients Undergoing Cardiac Surgery: a Randomized Controlled Trial

To assess the impact of influenza vaccination on the overall systemic inflammatory response in patients undergoing cardiac surgery and investigate functional and clinical outcomes in vaccinated patients postoperatively.

Inclusion Criteria: * Subjects who the investigator believes can and will comply with the requirements of the protocol (i.e. return for follow-up visits, and able to converse with study personnel) * Age 18 years or older * Undergoing major cardiac surgery using cardiopulmonary bypass Exclusion Criteria: * Have not received influenza vaccination in the past or cannot be vaccinated due to previous severe reaction to influenza vaccine, egg, latex, or thimerosol allergies, or refusal of vaccination * Participant has received a community available influenza vaccine within \10 mg daily, recent chemotherapy treatment) * Emergency cases as determined by the investigator or physician