Myeloid Derived Suppressor Cells Control by Signal Regulatory Protein-alpha: Investigation in Hepatocellular Carcinoma

project is to study and develop anti-Signal Regulatory Protein α (SIRPα) antibodies (Ab) as a new immunotherapy strategy in cancer. Samples harvested from hepatocellular carcinoma (HCC) and ovarian cancer patients will be used in evaluation of the SIRP-CD47 expression and of the effect of the anti-human Signal Regulatory Protein (hSIRP) Ab on various cellular types from patients and healthy volunteers.

Inclusion Criteria: * adult * HCC patients (all BCLC stages accepted) * patient consent for the use of their biological samples Exclusion Criteria: * patient with other cancers * hepatitis C or B positive * HCC treatment by chemo-embolization under 3 months * under Sorafenib treatment within the month prior to collection * underage or under guardianship patients