Predictive Value of PIIINP and Urinary NGAL in Renal Function Recovery

Conditions: Acute Renal Failure, Acute Kidney Tubular Necrosis, Chronic Kidney Failure

Sex: All

Ages: 18 Years – N/A

Healthy volunteers: No

Enrollment: 287

Sponsor: Nantes University Hospital

Summary

Acute Renal Failure (ARF) is defined by a severe, and usually reversible, glomerular filtration rate decreasing. Acute Tubular Necrosis (ATN) remain the major cause of ARF involving distress and destruction of tubular cells. This specific typology of ARF may evolve toward Chronic Renal Failure (CRF) concretizing a major public health issue. Predict the progression of ARF towards CRF appears essential. The investigators believe that the PIIINP and urinary NGAL biomarkers may constitute robust biomarkers of progression risk towards CRF.

Eligibility Criteria

Inclusion Criteria: * off-age patient. * ATN diagnosis based on 1) typical clinical environment (sepsis, nephrotoxicity...) 2) 50% decrease of glomerular filtration flow (according clearance MDRD) or more than 100micromol plasmatic creatinine increase. 3) no renal function improvement after efficient vascular filling (\>750cc normal saline or equivalent). * Consent. Exclusion Criteria: * ARF not related with ATN context. * Life expectancy less than 3 months. * Protocol refusal

Interested in this study? View the official listing for contact and enrollment details.

View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT02889575). StuddyBuddy aggregates publicly available trial information.