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Completed
NCT03440970
Mechanism and Effects of Manipulating Chloride Homeostasis in Stable Heart Failure
Conditions: Decompensated Heart Failure
Sex: All
Ages: 18 Years – N/A
Healthy volunteers: No
Phase: EARLY_PHASE1
Enrollment: 20
Sponsor: Yale University
Location: Yale University New Haven Connecticut
Summary
This study is designed to investigate the quantitative effects of sodium-free chloride supplementation on electrolyte balance, volume status, and sodium avidity in stable heart failure patients in a highly controlled environment.
Eligibility Criteria
Inclusion Criteria:
* Meticulous history of medical compliance and attendance of appointments
* Stable heart failure as defined by:
1. Absence of hospitalizations for 90 days
2. Stable diuretic and medical therapy for 30 days
3. Opinion of the patient's treating physician (Heart Failure Cardiologist) that the patient is at optimal volume status
* Evidence based heart failure treatment with maximally-tolerated doses of a beta blocker, ACE/ARB/neprilysin inhibitor and aldosterone antagonist
* Chronic loop diuretic therapy with ≥ 40 mg of furosemide equivalents
* Serum chloride \ 200 mg/dL while inpatient will not be enrolled.
* Serum bicarbonate level \
Source: ClinicalTrials.gov (NCT03440970). StuddyBuddy aggregates publicly available trial information.
