A 90 Day, Phase 3,Open Labeled Exploratory Study of RELiZORB

Children with inadequate intestinal absorption due to loss of large amounts of small bowel require intravenous nutrition (feeding through the vein) to sustain hydration and nutrition to avoid starvation and dehydration; however, intravenous (IV) nutrition can lead to complications including liver failure. Tube feeding directly to the small intestine avoids the complications of IV nutrition, but fats are not fully digestible due to inadequate bowel function. We propose to predigest the fat using a small cartridge attached to the feeding tube to allow for rapid absorption with the possibility of reducing or eliminating the need for intravenous nutrition

Inclusion Criteria: 1. Male or female patients, ages 2 years to 18 years, inclusive. 2. Diagnosed with SBS, as determined by medical history and PN dependence (i.e. need for PN for \>60 days after intestinal resection or a bowel length \10ml/hr but \400 mg/dL at screening. 4. Pancreatic insufficiency as defined as the use of pancreatic enzymes within 30 days prior to screening. 5. Evidence of untreated intestinal obstruction or active stenosis, as determined by the investigator. 6. Unstable absorption due to cystic fibrosis or known DNA abnormalities (i.e., familial adenomatous polyposis, Fanconi syndrome) as determined by the investigator. 7. History of microvillus inclusion disease, as determined by medical history. 8. Severe known dysmotility syndrome (i.e., pseudo-obstruction, gastroschisis-related motility disorders), as determined by the investigator. 9. Initiation of teduglutide or other GLP-2 analogues within 6 months of screening 10. Use of growth hormone, or supplemental glutamine within 3 months prior to screening. 11. Use of cisapride within 30 days prior to screening. 12. Active clinically significant pancreatic or biliary disease, as determined by the investigator. 13. Patients are receiving formulas that are not compatible with the RELiZORB cartridge (example, insoluble fiber-containing formulas) 14. Determined by the investigator to be unsuitable for participation for any reason.