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Completed NCT03603730

Vagal Nerve Stimulation for Interoception Modulation

Conditions: Healthy Adult

Sex: All
Ages: 18 Years – 65 Years
Healthy volunteers: Yes
Phase: NA
Enrollment: 25
Sponsor: Massachusetts General Hospital

Location: Massachusetts General Hospital Boston Massachusetts

Summary

Explore the effects of variable ingested volumes and auricular transcutaneous vagal nerve stimulation (taVNS) on brain and stomach outcomes in healthy adults.

Eligibility Criteria

Inclusion Criteria: * Male and female patients aged 18 and 65 years old (inclusive) * Comprehension of instructions * Avoidance of alcohol, nicotine, and caffeine for 25 hours prior to study session Exclusion Criteria: * BMI (Body Mass Index) more than 32 and/or weight \> 235 lbs. (limits of the MRI table) * Any other significant medical disease (systemic or CNS), psychiatric disorder, or chronic pain condition/s * Epilepsy or a prior history of seizures * Psychotropic medications or other medications that effect neurovascular coupling (i.e. fMRI) * Subjects taking illicit drugs or opioids * Allergy to pineapple (used in the test meal during MRI) * Contraindications for MRI: High magnetic fields may pose a serious health hazard to subjects with implanted ferromagnetic objects. Every subject in this study will be carefully screened before entering the high magnetic field shielded room to collect a precise outline of the subject's medical history. Subjects with the following characteristics/disease will not be eligible to participate in the study: -History of Head Trauma -Any metallic implants (e.g. braces or permanent retainers) -Tattoos with metallic ink above the nipple line -Surgical Aneurysm Clips -Cardiac Pacemaker -Prosthetic Heart Valve -Neurostimulator -Implanted pumps -Cochlear Implants -Metal rods, Plates -Screws -Recent Previous Surgery -IUD -Hearing Aid -Dentures (which might create NMR artifacts) -Metal Injury to eyes -Pregnancy or plans to become pregnant -Breast Feeding -Meniere's Disease -Transdermal (skin) patches such as NicoDerm (nicotine for tobacco dependence), Transderm Scop, or Ortho Evra (birth control) -Non-normally cycling females -Claustrophobia

Interested in this study? View the official listing for contact and enrollment details.

View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT03603730). StuddyBuddy aggregates publicly available trial information.