Serum and Bronchoalveolar Inflammatory Parameters in Patients With Severe Adult Respiratory Distress Syndrome

Conditions: H1N1 Influenza

Sex: All

Ages: 18 Years – N/A

Healthy volunteers: No

Enrollment: 97

Sponsor: Centre Hospitalier Universitaire, Amiens

Location: CHU Amiens-Picardie Amiens

Summary

Mannose-binding lectin (MBL) plays an important role in the innate immune response. In addition to activating the complement, MBL can induce cytokine production and contribute to a deleterious inflammatory response with severe A(H1N1)pdm09 virus infection. The aim was to determine if serum MBL levels correlate with the risk of mortality in intensive care units (ICU) patients with A(H1N1)pdm09 infection. Prospective observational study was performed in ICU patients with acute respiratory distress syndrome due to influenza A(H1N1)pdm09 virus. Demographic characteristics and severity indices were recorded at ICU admission. MBL was assayed from blood drawn at influenza diagnosis within 24-48 h following the ICU admission. Outcomes were compared according to MBL levels.

Eligibility Criteria

Inclusion Criteria: * Patients who developed moderate-to-severe ARDS defined by the presence of bilateral alveolar images, a PaO2 / FiO2 ratio \

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Source: ClinicalTrials.gov (NCT03641690). StuddyBuddy aggregates publicly available trial information.