High Dose Vitamin A in Preventing Gastrointestinal GVHD in Participants Undergoing Donor Stem Cell Transplant

This phase I trial studies the side effects and how well high dose vitamin A works in preventing gastrointestinal graft versus host disease (GVHD) in participants undergoing donor stem cell transplant. Vitamin A deficiency is associated with increased risk of gastrointestinal GVHD. Vitamin A regulates growth and differentiation of intestinal cells and may reduce risk of gastrointestinal GVHD.

Inclusion Criteria: * Adult patients planned to undergo an allogeneic stem cell transplant (SCT) with an human leukocyte antigen (HLA)-matched (unrelated or related) or 1 allele mismatched (7/8) donor or haploidentical donor who received either myeloablative or nonmyeloablative conditioning for hematologic malignancies are eligible Exclusion Criteria: * Vitamin A hypersensitivity or allergy * Abnormal liver enzymes outside of the institutional laboratory normal range within 30 days of screening * Abnormal total, indirect, or direct bilirubin outside of the institutional laboratory normal range within 30 days of screening * Enteral feeding intolerance * Medication intolerance - history of allergic reaction to Vitamin A or other history of discontinuation to study drug due to adverse effect * Pregnancy