Mechanisms of CBD for Chronic Pain

This is a study designed to examine the neurochemical mechanisms associated with Cannabidiol (CBD) versus placebo for chronic non-cancer pain.

Inclusion Criteria: * Age between 18-50 yrs. * Chronic musculoskeletal and joint pain for at least 3 months or longer. * Participants must live within a 60 mile radius of Salt Lake City, Utah to be eligible. Exclusion Criteria: * Current or past neurological illness. * Substance abuse or dependence within the prior 90 days. * Contraindication to brain MRI. * Type I and type II diabetes. * Unstable medical conditions. * Consumption of more than 2 drinks of alcohol per night. * Current pregnancy or planning to become pregnant or breastfeeding. * History of seizures or head trauma at PI discretion. * Active or history of major mental illness * Use of opioid medications in the past 30 days. * LFT results 3 times greater than the upper limit of normal at the screening. * Participants may be excluded if the PI feels they do not meet safety criteria.