Exploring the Anti-inflammatory Properties of Cannabis and Their Relevance to Insulin Sensitivity

This study tests the effects of cannabinoid levels in blood on inflammation and insulin sensitivity both acutely and chronically in individuals across the weight spectrum. To that end, the study employs two observational designs: 1) A study of acute effects with intermittent cannabis users and 2) A study in which current cannabis users will select one of three cannabis strains for four weeks and are compared to a matched control group who do not use cannabis to study chronic effects. Blood levels of THC and CBD, inflammatory biomarkers, and insulin resistance will be measured in both studies.

Inclusion Criteria: * Able to provide informed consent * Cannabis users in Study A must have smoked or vaped cannabis at least once since January 1st 2014 with no negative effects but NOT used in the past three months * Cannabis users in Study B must have been a regular (at least weekly) user for at least a year * Non-users in Study B cannot have used any cannabis in the previous year * Weight stable (\