Attribution of Toxicities Due to Radiotherapy and Immuno-Biological Therapies

Every year, new molecular agents enter the market with more and more patients receiving these treatments, especially in the metastatic setting. These molecular agents could correspond to immunotherapy and modulators of signaling pathways. More than 50% of cancer patients will receive radiation therapy during the course of their illness, including radiotherapy aimed a palliating symptoms secondary to metastatic diseases. Therefore, there will be an increasing number of patients who will be receiving radiotherapy while they are still receiving molecular agents. A better understanding of the interaction of these two treatment modalities is needed.

Inclusion Criteria: * Consent to be part of the AtTRIBut registry * Prior histological diagnosis of primary cancer. * If the patient has metastatic disease, there must be radiological or pathological evidence of metastasis * Age\> 18 years * Receiving a molecular therapy * Indicated to receive radiotherapy * Radiation therapy can be administered using 3D conventional, IMRT or SBRT techniques. Exclusion Criteria: • Refusal or inability to receive radiotherapy