Pain in Fibrous Dysplasia

Pain remains a common and frequently debilitating symptom, particularly during adulthood of Fibrous Dysplasia/McCune-Albright Syndrome (FD/MAS). For many FD/MAS patients, the amount of pain perceived is not commensurate with the level of detectable musculoskeletal pathology. Using a combination of clinical and biological assessments, this investigation aims to understand what drives pain in FD/MAS.

Inclusion Criteria (FD/MAS patients): * Male and Female subjects * 10-45 years of age * English Speaking ability sufficient to comprehend consent (with parental assistance if minor) * Diagnosis of Fibrous Dysplasia Exclusion Criteria for patients: * Younger than 10 or older than 45 years old * Weight \> 285 lbs (weight limit of the MRI table and \< 36lbs) * Surgery leaving implanted material * Contraindications to MRI scanning and PET scanning (including presence of a cardiac pacemaker or pacemaker wires, metallic particles in the body, vascular clips in the head or previous neurosurgery, prosthetic heart valves, claustrophobia, previous significant research related exposure to ionizing radiation) Exclusion Criteria for healthy controls: Same as for the patients, with the addition of the following: • Use of recreational or illicit drugs History of chronic pain