Breathing-Maneuver-Induced Myocardial Oxygenation Reserve Validated by FFR (B-MORE)

The study aims to determine a diagnostic marker for regionally impaired myocardial oxygenation response in patients with suspected coronary artery stenosis.

Inclusion Criteria: Healthy Participants * Age: \> 40y * No known current or pre-existing significant medical problems that would affect the cardiovascular or respiratory system. CAD Patients * Age \> 18 y * Indication for invasive coronary angiography based on symptoms and a test positive for inducible coronary ischemia, or previous coronary angiography. Exclusion Criteria: ALL participants: * General MRI contraindications: Pacemakers, defibrillating wires, implanted defibrillators, intracranial aneurysm clips, metallic foreign bodies in the eyes, knowledge or suspicion of pregnancy. * Consumption of caffeine (coffee, tea, cocoa, chocolate, "energy drink") during the 12 hours prior to the exam. * Regular nicotine consumption during the last 6 months. Patients only * Vasoactive medication (e.g. nitro) during the 12 hours prior to the exam Contraindications to adenosine (2nd or 3rd A-V block, sinus node disease, asthma, bronchoconstrictive diseases). * Acute Coronary Syndrome (ACS), or previous Coronary Artery Bypass Surgery * Previous myocardial infarction within 1 month * Clinically unstable condition * Significant or uncontrolled arrhythmia