Tailored Drug Titration Using Artificial Intelligence

The purpose of the ARTERY Outcomes study is to compare optima-for-blood pressure (optima4BP), a clinical decision support system for hypertension (HTN) treatment optimization to standard of care in patients with essential HTN.

Inclusion Criteria: * Two or more blood pressure (BP) readings of ≥ 140/90 mmHg during UCSF primary care or cardiology office visits within the last 12 months * Therapy with medications from at least 1 anti-HTN pharmacological agents at the time of the last office visit * At least minimally "tech-savvy" defined as Ownership of a compatible smartphone and Ability to access the internet * Active Electronic Health Record MyChart account Exclusion Criteria: * Home anti-HTN medication therapy doesn't match the electronic health record medication list * Anti-HTN medication therapy changed within 30 days prior to enrollment * Inability to operate a BP cuff * Incompatible smartphone device (Galaxy S5 Android 5.0) * Less than minimally "tech-savvy" defined as Inability to use the Internet * Non-compliance with medical follow-up (\>3 "no shows" in the previous 12 months) * Planned coronary revascularization in the next 12 months * Myocardial infarction, coronary revascularization, stroke, cardiac or aortic surgery in the previous 90 days * GFR \< 30 (CKD stage IV/ V) * Treating physician rules out the patient due to superseding health management concerns * Treating physician rules out the patient due to other concerns