Genotypic Influences on Network Progression in Parkinson's Disease

Sex: All

Ages: 40 Years – 75 Years

Healthy volunteers: No

Enrollment: 17

Sponsor: Northwell Health

Summary

In this longitudinal study, the investigators will follow Parkinson's disease (PD) patients with and without glucocerebrosidase (GBA) mutations. The investigators hypothesize that the rate of increase in brain network activity over time (network progression rate) is faster in patients with GBA gene mutations.

Eligibility Criteria

Inclusion Criteria: * Diagnosis of PD made according to United Kingdom (UK) Parkinson's Disease Society Brain Bank Criteria * Ability to provide written informed consent * Age 40-75 * Stable dose of antiparkinsonian medication for \>1 month prior to study entry Exclusion Criteria: * Subjects with pathogenic mutations in LRRK2 related PD mutations (subjects with variants of uncertain significance (VUS) are eligible * History of known causative factors such as encephalitis or neuroleptic treatment * Patients with dementia (defined as Mini-Mental Status Exam score \

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View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT04228172). StuddyBuddy aggregates publicly available trial information.