Effects of Aerobic Exercise on Cognition,Cerebral Brain Flow and Mental Health Among Traumatic Brain Injury Patients

The aim of this study is to develop exercise prescription of TBI patients and then to evaluate the effectiveness of programmed aerobic walking exercise to improve cognitive performance, depression relief, motivation, symptom, resilience and quality of life with improvement of CBF. This will be a randomized controlled clinical trial, using a mixed method to explore the feasibility and validity of such a safety exercise prescription. Then, a randomized clinical control trial will be applied in TBI patients to evaluate the effectiveness of programmed aerobic exercise to promote psysical-psycho-social health such as cognitive status, 6 minutes walk test, depression relief, motivation, symptom, resilience and quality of life.

Inclusion Criteria: 1. Patients who have been diagnosed with mild traumatic brain injury at the emergency department 2. GCS score of 14-15 at the emergency department or patients with moderate brain injury (GCS score of 8-13 3. Brain injury Patients more than three months after discharge 4. Can communicate in Chinese and Taiwanese 5. Patients who have good audio-visual ability to complete tests and data filling 6. Patients are willing to sign a consent form to participate in the research. 7. Each subject was able to walk on their own, communicate freely and live in Taipei or Greater Taipei. Exclusion Criteria: 1. Exclude those with severe impairment of cognition, emotions and executive function caused by prefrontal lobe injury 2. Exclude patients with brain injury due to head puncture. 3. Regularly perform moderate-intensity aerobic exercise.