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Active Not Recruiting NCT04337255

Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diet in Stroke Patients Patients

Conditions: Cognitive Decline, Dementia, Vascular, Alzheimer Disease, Dementia, Stroke

Sex: All
Ages: 55 Years – N/A
Healthy volunteers: No
Phase: NA
Enrollment: 266
Sponsor: Rush University Medical Center

Location: Rush University Medical Center Chicago Illinois

Summary

To test the effects of a 2- to 3-year intervention of the MIND diet versus usual post-stroke care on cognitive decline, the characteristic feature of dementia, and on brain biomarkers of Alzheimer's Disease (AD) and vascular disease in a Phase Ill randomized controlled trial of 250 patients hospitalized for acute ischemic stroke, aged 55 years or older, and without dementia who are discharged home following hospitalization.

Eligibility Criteria

* Inclusion Criteria * Men and women, 55 years of age - inclusive- or older * Acute stroke as defined by an acute focal neurological deficit in combination with one of the following: acute ischemic infarct (stroke) as documented by either a DWl positive lesion on MR imaging or a new lesion on a delayed CT scan * Written informed consent by patient prior to study participation * Willingness to complete all assessments and participate in follow-up * Willing to participate and give informed consent * Adequate Visual and auditory acuity to undergo neuropsychological testing * Exclusion criteria * CDR\>=0.5 * Nuts, berries, olive oil, or fish allergies * Use of medications to treat Alzheimer's disease or Parkinson's disease * Aphasia * Conditions of psychosis or bipolar disorder judged by study investigators to potentially interfere with study compliance over 3 years * Report of alcohol or substance abuse within six months, or heavy alcohol consumption (\>2 drinks/d women; \>3 drinks/d men) * Unstable or recent onset of cardiovascular disease, such as myocardial infarction within six months or presence of congestive heart failure (Stages II-IV) * Cancer treatment \

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Source: ClinicalTrials.gov (NCT04337255). StuddyBuddy aggregates publicly available trial information.