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Active Not Recruiting
NCT04337255
Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diet in Stroke Patients Patients
Conditions: Cognitive Decline, Dementia, Vascular, Alzheimer Disease, Dementia, Stroke
Sex: All
Ages: 55 Years – N/A
Healthy volunteers: No
Phase: NA
Enrollment: 266
Sponsor: Rush University Medical Center
Location: Rush University Medical Center Chicago Illinois
Summary
To test the effects of a 2- to 3-year intervention of the MIND diet versus usual post-stroke care on cognitive decline, the characteristic feature of dementia, and on brain biomarkers of Alzheimer's Disease (AD) and vascular disease in a Phase Ill randomized controlled trial of 250 patients hospitalized for acute ischemic stroke, aged 55 years or older, and without dementia who are discharged home following hospitalization.
Eligibility Criteria
* Inclusion Criteria
* Men and women, 55 years of age - inclusive- or older
* Acute stroke as defined by an acute focal neurological deficit in combination with one of the following: acute ischemic infarct (stroke) as documented by either a DWl positive lesion on MR imaging or a new lesion on a delayed CT scan
* Written informed consent by patient prior to study participation
* Willingness to complete all assessments and participate in follow-up
* Willing to participate and give informed consent
* Adequate Visual and auditory acuity to undergo neuropsychological testing
* Exclusion criteria
* CDR\>=0.5
* Nuts, berries, olive oil, or fish allergies
* Use of medications to treat Alzheimer's disease or Parkinson's disease
* Aphasia
* Conditions of psychosis or bipolar disorder judged by study investigators to potentially interfere with study compliance over 3 years
* Report of alcohol or substance abuse within six months, or heavy alcohol consumption (\>2 drinks/d women; \>3 drinks/d men)
* Unstable or recent onset of cardiovascular disease, such as myocardial infarction within six months or presence of congestive heart failure (Stages II-IV)
* Cancer treatment \
Source: ClinicalTrials.gov (NCT04337255). StuddyBuddy aggregates publicly available trial information.