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Completed
NCT04353778
Effects of Vagal Dysfunction on Gastrointestinal and Inflammatory Pathways in HIV
Conditions: HIV, Non-HIV, Vagus Nerve Dysfunction
Sex: All
Ages: 18 Years – N/A
Healthy volunteers: Yes
Phase: PHASE1, PHASE2
Enrollment: 215
Sponsor: Icahn School of Medicine at Mount Sinai
Location: Icahn School of Medicine at Mount Sinai New York New York
Summary
The study team's prior research has shown that dysfunction of a specific nerve, called the vagus nerve, is associated with small intestinal bacterial overgrowth (SIBO), and that SIBO is associated with signs of inflammation in the blood of people living with HIV (PLWH). This research will explore pathways linking vagal dysfunction to inflammation in HIV, focusing on the gastrointestinal tract, and study whether a medication called pyridostigmine and stimulation of the vagus nerve are beneficial therapies.
Eligibility Criteria
Inclusion Criteria :
* Greater than or equal to18 years old (18 to 64 Years, 65 Years and Over)
* Documentation of HIV-1 infection
* Stable CART for greater or equal to 3 months
* HIV-1 viral load \
Source: ClinicalTrials.gov (NCT04353778). StuddyBuddy aggregates publicly available trial information.
