Project HOPE 1000: Health Outcomes Pregnancy Exposures

The purpose of this study is to collect biological samples from pregnant women and their babies and to collect data on long-term health, school outcomes, and the use of state and county services. The information learned from this study may help identify important factors that may influence the health of mothers and babies, both short-and long-term.

Inclusion criteria: * The subject has provided a signed Informed consent prior to any study procedures. * Maternal age at consent of ≥ 18 years old * Ability to understand English or Spanish * Willingness to comply with and be available for all protocol procedures * Singleton gestation \< 24 weeks 0 days * Receiving prenatal care at a Duke-affiliated Obstetrics clinic with the intent of delivering at Duke University Health System-affiliated hospital (including Duke University Hospital and Duke Regional Hospital) * Plans to have their infant seen at a Duke-affiliated Pediatrics practice after birth * Plans to remain in the area for two years after delivery Exclusion criteria: * Non-viable pregnancy * Having any condition that, in the opinion of the site investigators, would place the subject at unacceptable risk of injury or confound data interpretation