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Enrolling By Invitation
NCT04430426
Heterozygous Individuals for AGXT and Kidney Stones
Conditions: Kidney Stone, Urolithiasis, Calcium Oxalate
Sex: All
Ages: 18 Years – N/A
Healthy volunteers: No
Phase: NA
Enrollment: 4
Sponsor: University of Alabama at Birmingham
Location: University of Alabama at Birmingham Birmingham Alabama
Summary
This study seeks to examine the effects of a heterozygous mutation of the AGXT gene in a stone forming population on endogenous oxalate production. Participants will consume a controlled low-oxalate diet and provide blood and urine samples to measure the amount of oxalate in their bodies.
Eligibility Criteria
Inclusion Criteria:
* at least 18 years of age
* history of calcium oxalate stones
* heterozygous mutation of the AGXT gene, as evidenced by results from the Invitae Nephrolithiasis Panel
* willingness to comply with a controlled diet for five days
Exclusion Criteria:
* pregnant individuals
* individuals who are currently breast feeding
Source: ClinicalTrials.gov (NCT04430426). StuddyBuddy aggregates publicly available trial information.
