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Active Not Recruiting
NCT04499534
BRCA1/2 Flu Vaccine
Conditions: BRCA1 Mutation, BRCA2 Mutation
Sex: All
Ages: 25 Years – N/A
Healthy volunteers: Yes
Enrollment: 50
Sponsor: Abramson Cancer Center at Penn Medicine
Location: University of Pennsylvania Philadelphia Pennsylvania
Summary
To evaluate immune function in BRCA1/2 mutation carriers without cancer, specifically to determine whether immune function in healthy individuals with germline loss of function BRCA1/2 mutations, impacts overall immune health and fitness.
Eligibility Criteria
Inclusion Criteria:
* Males and females
* Over age 25
* BRCA1 or BRCA2 pathogenic or likely pathogenic mutation
* No personal cancer history apart from non melanoma skin cancer, localized thyroid cancer, in situ cancers of any type
* Participants must sign the informed consent form
Exclusion Criteria:
* Are allergic to influenza vaccination
* Have received influenza vaccination within the past 6 months
* Require prednisone, methotrexate, or other immunosuppressing medications
* Have HIV infection
* Have a history of solid organ tumor or bone marrow transplant
* Require combination immunotherapy;
* Are on other studies requiring blood draws that might exceed 450 mL total during the period of the influenza vaccine study
Source: ClinicalTrials.gov (NCT04499534). StuddyBuddy aggregates publicly available trial information.
