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Recruiting
NCT04600115
New MRI Methods Applied to Heart Failure With Preserved Ejection Fraction (HFpEF)
Conditions: MRI Scans
Sex: All
Ages: 18 Years – N/A
Healthy volunteers: Yes
Phase: EARLY_PHASE1
Enrollment: 100
Sponsor: University of Utah
Location: university of Utah, Radiology Research Salt Lake City Utah
Summary
This study's main specific aims are;
1. To develop robust acquisition and reconstruction methods specifically for the study of microvascular cardiac remodeling with MRI which will include very innovative quantitative perfusion methods, as well as fibrosis quantification, longitudinal strain, and phase contrast imaging for flow.
2. Test the new methods for identifying the clinical task of characterizing HFpEF.
Eligibility Criteria
Inclusion Criteria:
* All participants will be over the age of 18 and able to provide consent
* Group A (volunteers, with or without cardiac disease): Volunteers will be available for at least one study visit
* Group B (HFpEF patient volunteers): Volunteers will have a diagnosis of HFpEF and be safe to be imaged with MRI
Exclusion Criteria:
* minors
* Critically ill patients, patients on ventilators, patients with unstable angina or with hypotension, asthmatics, and other patients whose medical care or safety may be at risk from undergoing an MRI examination will be excluded.
* Patients with claustrophobia will also be excluded from the study if this cannot be controlled with standard methods (valium or benadryl).
* Patients with contraindication to MRI (metal implants, or certain types of heart valves),
* pregnant patients, , mentally disabled patients and prisoners will be excluded from this study. (All criteria apply to patients and normal volunteers).
* Gadolinium nephrotoxicity will be addressed by having patients with abnormal kidney function (GFR\
Source: ClinicalTrials.gov (NCT04600115). StuddyBuddy aggregates publicly available trial information.