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Active Not Recruiting
NCT04676399
Improving Pain Management Via Spinal Cord Stimulation and Blood Pressure Reduction
Conditions: Chronic Pain, Hypertension, Diuretics Drug Reactions, SCS
Sex: All
Ages: 40 Years – 79 Years
Healthy volunteers: No
Phase: EARLY_PHASE1
Enrollment: 36
Sponsor: University of Kansas Medical Center
Location: The Marc A. Asher Comprehensive Spine Center at the Kansas University Medical Center Kansas City Kansas
Summary
The purpose of this study (PASSION study) is to monitor symptoms of chronic pain before and after 2 weeks of a standard drug commonly used to treat elevated blood pressure compared with 2 weeks of placebo (crossover design) so that we may better understand how blood pressure affects your level of pain. This study is not testing an experimental drug.
Eligibility Criteria
Inclusion Criteria:
1. Male or Female, age 40-79
2. Chronic low back pain
3. Permanent spinal cord stimulator implant for chronic pain
4. Stage 1 hypertension (BP 130-139/80-89 mmHg) with ASCVD risk ≥10%
5. Stage 2 hypertension (BP ≥ 140/90 mmHg)
6. Willing to visit research lab (Fairway CTSU)
7. Willing to undergo a blood draw
8. Able to provide written informed consent
Exclusion Criteria:
1. Any history of abnormal responses (allergy) to thiazide-type drugs
2. Currently taking any antihypertensive medication
3. Stage 1 hypertension (BP 130-139/80-89 mmHg) with ASCVD risk \
Source: ClinicalTrials.gov (NCT04676399). StuddyBuddy aggregates publicly available trial information.
