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Recruiting
NCT04708613
University of Pittsburgh Brain Health Initiative
Conditions: Traumatic Brain Injury
Sex: Male
Ages: 29 Years – 59 Years
Healthy volunteers: Yes
Enrollment: 300
Sponsor: David Okonkwo, MD, PhD
Location: University of Pittsburgh Department of Neurosurgery Pittsburgh Pennsylvania
Summary
This project will define the prevalence of brain health (i.e., normal cognitive, neuromotor, behavioral function) in living professional football retirees and group-matched controls through a comprehensive assessment of clinical, neuroimaging, and biomarker measures.
Eligibility Criteria
Inclusion criteria:
Former professional football player/exposed group:
1. Professional football retiree aged 29-59
2. Played a minimum of 3 professional football seasons, with a minimum of 3 games in each season
3. Fluent in English (translations are not available/validated for most neuropsychological tests)
Control/unexposed group:
1. Age 29-59 male
2. High school education or beyond
3. Fluent in English (translations are not available/validated for most neuropsychological tests)
Exclusion criteria:
Control/unexposed group:
1. Played organized football beyond high school
2. History of severe TBI
3. Current unstable cardiovascular disorder
For both groups:
1. Prior history of psychosis (such as schizophrenia), or other major neurological disorder that would interfere with testing, in the opinion of the primary investigator.
2. Contraindication to MR imaging, such as ferrous metal, pacemakers, or concerns about claustrophobia
Source: ClinicalTrials.gov (NCT04708613). StuddyBuddy aggregates publicly available trial information.
