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Completed
NCT04949529
Falls: A Marker of Preclinical AD
Conditions: Fall, Alzheimer Disease
Sex: All
Ages: 65 Years – N/A
Healthy volunteers: Yes
Enrollment: 355
Sponsor: Washington University School of Medicine
Location: Washington University School of Medicine St Louis Missouri
Summary
This longitudinal cohort study investigates cognitively normal participants with and without preclinical Alzheimer disease (AD) in order to examine: (1) the relationship between falls and functional mobility in preclinical stages of AD; and (2) a hypothesized model of central and peripheral mechanism(s) underlying falls and functional mobility in preclinical stages of AD.
Eligibility Criteria
Inclusion Criteria:
1. 65 years of age or older
2. cognitively normal (Clinical Dementia Rating \[CDR\] score of 0)
* A pilot sub-study collecting stool will also enroll a few individuals with CDR\>0 for comparison.
3. have biomarkers (CSF), and/or neuroimaging (positron emission tomography \[PET\] and/or magnetic resonance imaging \[MRI\]) within 2 years of enrolling in this study.
Exclusion Criteria:
* History of Parkinson's disease.
Source: ClinicalTrials.gov (NCT04949529). StuddyBuddy aggregates publicly available trial information.
