Restricted or Liberal Antibiotics After Appendectomy - Denver Health

The purpose of this study is to see if decreasing the amount of antibiotics after appendicitis surgery can decrease the risk of adverse effects associated with antibiotics while at the same time ensuring participant safety.

Inclusion Criteria: * Age ≥ 18 years * Planned appendectomy (laparoscopic or open) for simple or complicated (perforated or gangrenous) appendicitis * Working telephone number or reliable method to contact patient after hospital discharge Exclusion Criteria: * Unable to consent * Pregnant Women * Prisoners * Immunocompromised as determined by clinical team, or patients actively receiving steroids, chemotherapy, or immunosuppressing medications (for example tacrolimus), or patients with active hematologic malignancy affecting the immune system, leukopenia, or end-stage AIDS * Heart failure * Allergy to bupivacaine * Unlikely to comply with treatment or follow-up * Inpatient consultation for appendicitis * Clinically suspected of sepsis based on Sepsis-3 definition * Current use of antibiotics for other indications * Uncontrolled hyperglycemia or Type 1 Diabetes * Surgeon preference * Patient preference * Research team unavailable