Intraarticular Dextrose Prolotherapy for Symptomatic Knee Osteoarthritis

The purpose of this research is to learn more about treating Symptomatic Knee Osteoarthritis (OA) with an ultrasound-guided hypertonic dextrose injection. Researchers would like to determine best practice for injection frequency and effectiveness of the dextrose injection for symptomatic knee OA.

Inclusion Criteria: * Diagnosis of knee OA by clinical criteria (American College of Rheumatology). * Identification of knee osteoarthritis by a radiologist on an existing knee radiograph obtained within 3 years of enrollment. * Moderate to severe knee pain for at least 3 months, defined as a score of ≥ 4 (on a 0-10 point numeric rating scale) in response to the question "What is the average level of your left/right knee pain in the past 3 months?". Exclusion Criteria: * Pregnancy. * Diabetes. * Anticoagulation therapy. * History of total knee replacement. * Prior knee prolotherapy or other regenerative product. * Any knee injection within 3 months. * Inflammatory (RA, gout, pseudogout etc.) or postinfectious knee arthritis. * Daily use of opioid medication. * Allergy or intolerance to study medication, corn allergy. * Body mass index (BMI) greater than 40 kg/m\^2. * Comorbidity severe enough to prevent participation in the study protocol. * Use of oral steroids during the study period * Use of injectable steroids in the past 3 months or during the study period