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Active Not Recruiting
NCT05180981
Imaging Brain Fluids During Breathing
Conditions: Healthy
Sex: All
Ages: 18 Years – 70 Years
Healthy volunteers: Yes
Phase: NA
Enrollment: 81
Sponsor: Boston University Charles River Campus
Location: Massachusetts General Hospital Boston Massachusetts
Summary
This study will perform magnetic resonance imaging (MRI) measurements of hemodynamics and cerebrospinal fluid flow across breathing tasks and during breath-locked neuromodulation.
Eligibility Criteria
Inclusion Criteria:
* Adult age 18-70 years
Exclusion Criteria:
* No ferrous metal implanted in head or body
* No history of major head trauma
* No neurological or psychiatric disorder
* Not using medication that affects brain function
* No implanted electronic devices (e.g. pacemaker)
* No implant that poses an MR contraindication
* Not pregnant, suspect they are pregnant, or seeking to become pregnant
* Not claustrophobic
* No piercings or jewelry that cannot be removed
* Does not weigh more than 250 pounds
* Normal or contact-corrected normal vision
Exclusion for transcutaneous vagus nerve stimulation (tVNS) arm:
* Conditions of skin or anatomy that affect left auricle or forehead skin and could impact placement of electrodes for tVNS or forehead stimulation
* Diagnosis of significant cardiovascular or cerebrovascular disease \[e.g. congestive heart failure, stroke, cardiac conduction disorders (including: bundle branch block, heart block, long Q-T syndrome), history of asystole or non-sustained ventricular tachycardia.
* Bradycardia (defined as resting heart rate \
Source: ClinicalTrials.gov (NCT05180981). StuddyBuddy aggregates publicly available trial information.