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Completed
NCT05261633
Diffusion MRI of the Abdomen
Conditions: Abdominal Imaging
Sex: All
Ages: 18 Years – N/A
Healthy volunteers: Yes
Enrollment: 17
Sponsor: University of Wisconsin, Madison
Location: University of Wisconsin School of Medicine and Public Health Madison Wisconsin
Summary
The purpose of this research is to see if a new magnetic resonance imaging (MRI) method will be able to improve the images taken of the abdomen. This new method includes some changes to help avoid movements that may disrupt the images like breathing, heartbeats and other involuntary motion that occurs in the abdomen. This study will these methods in healthy volunteers and validate them in patients with known liver metastases in a single contrast-enhanced MRI visit.
Eligibility Criteria
Inclusion Criteria for Healthy Volunteers:
* 18 years of age or older
Exclusion Criteria for Healthy Volunteers:
* Patients with contraindication to MRI (e.g. pacemaker, contraindicated metallic implants, claustrophobia, etc)
* Pregnant or trying to become pregnant (as determined by self-report during MRI safety screening)
Inclusion Criteria for Patients:
* 18 years of age or older
* Patients with at least one of the following:
* Radiologically visible solid tumor liver metastasis, with at least one metastatic liver lesion must be a minimum of 8 mm in longest diameter
* Patients presenting for liver lesion biopsy
Exclusion Criteria for Patients:
* Patients with contraindication to MRI (e.g. pacemaker, contraindicated metallic implants, claustrophobia, etc)
* Patients with known contraindication to GBCA such as severe kidney disease or previously documented GFR \< 30 ml/min/1.73 m2
* Patients requiring intravenous (IV) conscious sedation for imaging are not eligible; patients requiring mild, oral anxiolytics for the MRI will be allowed to participate as long as the following criteria are met:
* The subject has their own prescription for the medication.
* The informed consent process is conducted prior to the self-administration of this medication
* They come to the research visit with a driver
* Pregnant or trying to become pregnant (as determined by self-report during MRI safety screening)
* Stent in bile ducts
* Partial hepatectomy
Source: ClinicalTrials.gov (NCT05261633). StuddyBuddy aggregates publicly available trial information.