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Recruiting
NCT05384561
Olfactory Training as a Treatment for Olfactory Dysfunction Post COVID-19
Conditions: Hyposmia, COVID-19, Parosmia, Anosmia, SARS-CoV-2 Infection
Sex: All
Ages: 18 Years – N/A
Healthy volunteers: No
Phase: NA
Enrollment: 70
Sponsor: Université du Québec à Trois-Rivières
Location: Université du Québec à Trois-Rivières Trois-Rivières Quebec
Summary
Olfactory dysfunction is a defining symptom of COVID-19 infection. Studies have demonstrated improved olfaction in patients with post infectious olfactory dysfunction after an olfactory training (OT). The aim of this study is to assess the clinical outcomes of olfactory training (12 weeks) therapy in the treatment of persistent olfactory dysfunctions after COVID-19. Specially, we aim to compare the effectiveness of two different olfactory training (different odors).
A group will train themselves with 4 scents (rose, orange, clove and eucalyptus) and another group with 4 different scents (cheese, coffee, strawberries and lemon). Olfaction sensory evaluation will be performed by using different olfaction tests (Sniffin' Sticks and UPSIT) and complete questionnaires to assess olfactory perception and particularly parosmia and phantosmia.
Eligibility Criteria
Inclusion Criteria:
* Patient diagnosed positive for COVID-19 with persistent olfactory dysfunction
* Willing and able to provide written informed consent
* Understand and read the French language
* Have an internet connection and a working email address
Exclusion Criteria:
* Anosmia and hyposmia pre-covid-19
* Be known chronic rhinosinusitis with or without nasal polyposis
* Have received radiotherapy or chemotherapy for Head and Neck Tumors
* Have a diagnosis of Alzheimer's, Parkinson's, multiple sclerosis or any other neurodegenerative disease 5. Have a brain tumor or ENT diagnosis 6. History of naso-sinus surgery; 7. History of traumatic brain injury
Source: ClinicalTrials.gov (NCT05384561). StuddyBuddy aggregates publicly available trial information.