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Completed
NCT05388968
Metatranscriptomic Next Generation Sequencing in First Trimester Trophoblast With Increased Fetal Nuchal Translucency (METAHCN)
Conditions: Increased Nuchal Translucency in the First Trimester of Pregnancy
Sex: Female
Ages: 18 Years – N/A
Healthy volunteers: No
Enrollment: 78
Sponsor: Assistance Publique - Hôpitaux de Paris
Location: Hopital Necker - Enfants malades Paris
Summary
The study is based on the hypothesis that increased nuchal translucency may be associated with a materno fetal infection and that the pathogen responsible for this infection could be identify with metatranscriptomic next-generation sequencing in the trophoblast tissue.
Eligibility Criteria
Inclusion Criteria:
* Pregnant women
* Singleton pregnancy
* First trimester (11 GA+0D to 13 GA+6D)
* Carrying a fetus with a nuchal translucency \> 3.5 mm for which a chorionic villi sampling is performed OR a suspicion of genetic abnormalities for which a chorionic villi sampling is performed
* Delivery planned at Necker hospital
* Not opposed to participation
Exclusion Criteria
* Age \
Source: ClinicalTrials.gov (NCT05388968). StuddyBuddy aggregates publicly available trial information.
