Prandial Metabolic Phenotype in Adults

Previous studies suggest that changes in metabolism due to the effects of aging might serve as a potential for therapeutic agents. The investigating lab developed a pulse method combining multiple stable isotopes to study multiple metabolic pathways in the same individual simultaneously. By measuring whole-body metabolism in a large group of older adults, the investigators may be able to unravel age-related deterioration in protein turnover (synthesis and breakdown) that contributes to impaired functional capacity. Metabolic profiles could explain differences in pathways in the aging process with special interest in metabolism of amino acids as they have been associated with aging-related disorders.

Inclusion Criteria: * Age: 60-80, inclusive * Stable body-weight (± 5%) for the past 3 months * Subject is judged to be in satisfactory health based on medical history, physical examination, and laboratory screening evaluations. * Ability to walk, sit down and stand up independently or with walking mobility aids * Ability to lie in supine or elevated position for up to 7 hours * Willingness and ability to comply with the protocol Exclusion Criteria: * Established diagnosis of current malignancy * History of untreated metabolic diseases including hepatic or renal disorder * Presence of acute illness or metabolically unstable chronic illness * Presence of fever within the last 3 days * Use of short course of oral corticosteroids within 4 weeks preceding study day * (Possible) pregnancy * Failure to give informed consent or Investigator's uncertainty about the willingness or ability of the subject to comply with the protocol requirements * Already enrolled in another clinical trial and that clinical trial interferes with participating in this study * Any other condition according to the PI or nurse that was found during the screening visit, that would interfere with the study or safety of the patient