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Completed
NCT05423743
INSPIRE Trial for Abdominal Infections
Conditions: Abdominal (ABD) Infection
Sex: All
Ages: 18 Years – N/A
Healthy volunteers: No
Phase: NA
Enrollment: 198480
Sponsor: Harvard Pilgrim Health Care
Location: Riverside Community Hospital Riverside California
Summary
The INSPIRE Abdominal Infection Trial is a cluster-randomized controlled trial of HCA Healthcare hospitals comparing routine empiric antibiotic stewardship practices with real-time, precision medicine computerized physician order entry (CPOE) smart prompts providing the probability that a non-critically ill adult admitted with abdominal infection is infected with a resistant pathogen.
Note: enrolled "subjects" represent 102 individual HCA Healthcare hospitals that have been randomized into 92 clusters. Hospitals were grouped into the same randomization cluster if they shared campuses or antibiotic stewardship staff.
Eligibility Criteria
Facility Inclusion Criteria:
1. HCA Healthcare hospitals admitting adults for abdominal infection
2. Facility use of MEDITECH as their electronic health record system
Facility Exclusion Criteria:
\-
Note: unit of randomization is the hospital, however the computerized physician order entry (CPOE) alert intervention will calculate risk estimates for adults age \>=18 admitted to non-intensive care unit wards and who are ordered to receive extended-spectrum antibiotics for abdominal infection.
Source: ClinicalTrials.gov (NCT05423743). StuddyBuddy aggregates publicly available trial information.
