Neuroimaging Sleep and Mood in Depression

This study will investigate how sleep and mood are related in patients with depression and in healthy controls. It will use MRI-based measures of brain function to determine how neural systems are modulated by sleep and sleep deprivation, and its links to mood in depression.

Inclusion criteria: * Adult aged 18-80 Inclusion criteria for patient cohort only: \- Current diagnosis of major depressive disorder Exclusion criteria: * Must not have ferrous metal implanted in head or body * Must have no history of major head trauma * Must not have implanted electronic devices (e.g., pacemaker, neurostimulator) * Must not be pregnant, suspect they are pregnant, or seeking to become pregnant * Must not be claustrophobic * Must have no piercings or jewelry that cannot be removed * Weight less than 250 pounds * No lifetime history of schizophrenia or any other psychosis disorder, substantial intellectual disability, bipolar disorder, post-traumatic stress disorder or obsessive compulsive disorder * No alcohol or substance abuse or dependence within the past 6 months * No significant personality dysfunction * Must not indicate significant suicide risk. * Must not be taking medications that significantly affect sleep, psychiatric function, blood/vascular function, or anti-inflammatory medications (other than minor NSAID use).