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NCT05500170
Benefits of Nicotinamide Riboside Upon Cognition and Sleep
Conditions: Cognitive Impairment, Sleep Quality
Sex: All
Ages: 65 Years – 85 Years
Healthy volunteers: Yes
Phase: NA
Enrollment: 50
Sponsor: State University of New York at Buffalo
Location: State University of New York at Buffalo Buffalo New York
Summary
Poor sleep quality and short sleep duration may be a mechanistic component of cognitive impairment in older adults, associated with a decline in brain-derived neurotrophic factor. Increasing the availability of nicotinamide adenine dinucleotide (NAD+) with supplementation of its precursor, nicotinamide riboside (NR), a form of vitamin B3 may increase the expression of brain-derived neurotrophic factor. This study proposes to examine the benefits of NR supplementation on sleep and cognitive function in older adults with comprehensive subjective and objective measures and to explore its impacts on serum brain-derived neurotrophic factor.
Eligibility Criteria
Inclusion Criteria:
* Sleep Quality. Pittsburgh Sleep Quality Index (PSQI) global score \>5
Exclusion Criteria:
* Dementia. Veteran Affairs - St. Louis University Mental Status questionnaire (VA-SLUMS) score \
Source: ClinicalTrials.gov (NCT05500170). StuddyBuddy aggregates publicly available trial information.
