Intravenous Neonatal Central Access Safety Trial

Particulate contamination due to infusion therapy (administration of parenteral nutrition and medications) carries a potential health risk for infants in neonatal intensive care units (NICU). In-line filtration is increasingly used in critically-ill infants but its benefits, by preventing micro-particle infusion in neonates, remain to be demonstrated. In-line filters in the intravenous administration sets prevent the infusion of particles, which may reduce infectious complications.

Inclusion Criteria: * All patients admitted to NICU with at least one central venous catheter Exclusion Criteria: * Patients with peripheral venous catheter, patients with inflammatory episode at the time of enrollment