Therapeutic Mechanisms of Epidural Spinal Cord Stimulation

Sex: All

Ages: 18 Years – 89 Years

Healthy volunteers: No

Phase: NA

Enrollment: 80

Sponsor: University of Alabama at Birmingham

Summary

The purpose of this study in patients undergoing routine care epidural spinal cord stimulation (SCS) is to determine 1) whether SCS reduces arterial blood pressure (BP) in patients which chronic low back pain and hypertension, 2) whether higher baseline BP (i.e., hypertension) predicts reductions in pain following SCS, and finally 3) whether different SCS waveforms elicits stimulus-evoked compound action potentials (ECAPs) in spinal cord and at the cortex (electroencephalography, and magnetoenchphalography).

Eligibility Criteria

Inclusion Criteria: 1. Male or Female, age 18-89 2. Chronic pain for more than 3 months 3. Willing to visit a research lab 4. Willing to undergo a blood draw 5. Able to provide written informed consent Exclusion Criteria 1. History of neurological disease (e.g., dementias, Parkinson's) 2. History of stroke 3. Current diagnosis of cancer 4. Subject is unwilling or unable to comply with the protocol

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View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT05556902). StuddyBuddy aggregates publicly available trial information.