Evaluation of Viral Replication by Tonate Virus (TONV) and Zika Virus (ZIKV), Within an ex Vivo Trophoblast and Placental Model

Conditions: Zika Virus Infection

Sex: Female

Ages: 18 Years – N/A

Healthy volunteers: No

Sponsor: Assistance Publique - Hôpitaux de Paris

Summary

Prospective, non-interventional study carried out after culturing placental trophoblastic tissue ex vivo and infection with Zika and Tonate

Eligibility Criteria

Inclusion Criteria: * Patient over 18 years old * Singleton pregnancy of normal course, at term, birth by caesarean section OR * Trophoblast from Voluntary Termination of Pregnancy (IVG), after endo-uterine aspiration Exclusion Criteria: * Need for pathological, genetic or bacteriological examination of the placenta * Multiple pregnancy * HBV+ (Hepatitis B positive), HCV+ (Hepatitis C positive) , known CMV seroconversion during pregnancy (CytoMégaloVirus) * Immunosuppression (drugs, corticosteroids, etc.) * Diabetes * Pre eclampsia * Intrauterine growth retardation (IUGR), * Vascular or placental pathology. * Refusal to participate * Patient under guardianship / curatorship / security measure * Patient under AME (state medical aid)

Interested in this study? View the official listing for contact and enrollment details.

View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT05589012). StuddyBuddy aggregates publicly available trial information.