Shanghai At Risk for Alzheimer's Disease: a Cohort Study

The goal of this cohort study is to estimate the incidence of AD in the first-degree relatives of patients with AD. The main questions it aims to answer are:cognitive changes of subjects at high risk of AD as ageing;environmental and behavioral factors affecting AD incidence.

Inclusion Criteria:the AD diagnostic criteria of probands meet the 2011 National Institute on Aging - Alzheimer's Association framework, and participants are the first-degree relatives (including parents, children and siblings of the same father and mother) of the proband;not patients with dementia;≥ 50 years, males and females;subjects have lived in Shanghai for more than 1 year and have no plan to move out of Shanghai within 5 years;subjects are able to complete investigation, physical examination, imaging examination and biological specimen collection.Exclusion criteria:Individuals will be excluded if they have:other diseases which could cause cognitive decline, e.g. cerebrovascular diseases, Creutzfeldt-Jakob disease and Parkinsons disease;history of psychological disorders (according to Diagnostic and Statistical Manual of Mental Disorders, 5th Edition);uncorrectable visual or auditory impairment that hampers the completion of related examination.pre-menopausal women will also be excluded.