Effect of Remote Ischemic Conditioning on Cerebral Hemodynamics in Patients After Intravenous Thrombolysis (RICCH-IVT)

The purpose of this study is to determine the effect of remote ischemic conditioning on cerebral hemodynamics in patients after intravenous thrombolysis

Inclusion Criteria:age ≥ 18 and < 80 years, both sexes;a clear clinical diagnosis of acute ischemic stroke and treatment with standard rt-PA (0.9 mg/kg) IVT within 4.5 h of stroke onset;pre-onset modified Rankin Scale (mRS) score ≤1;baseline National Institute of Health Stroke Scale (NIHSS) score ≥5 and ≤25;Glasgow Coma Scale score ≥8.Exclusion Criteria:having received bridging therapy (IVT plus mechanical thrombectomy);previous history of atrial fibrillation or electrocardiographic evidence of atrial fibrillation;contraindications to RIC treatment or previous RIC treatment or similar treatment;pregnancy or breastfeeding;life expectancy of ≤3 months or inability to complete the study for other reasons;unwillingness to be followed up or poor treatment compliance or participation in other clinical studies;had insufficient bilateral temporal bone windows for insonation of the middle cerebral artery.