13C Pyruvate DNP MR Spectroscopy for Lymphoma Treatment Response Assessment

This study has two stages and the aims are as follows:Aim 1:In Stage 1 of this study, the investigators aim to recruit first-time diagnosed lymphoma patients, to understand the changes of metabolites before and after treatment, and to evaluate the ability of hyperpolarized 13C-labeled pyruvate from dynamic nuclear polarization (DNP) magnetic resonance spectroscopy (MRS) for detecting early treatment response in these patients.The pre-treatment metabolic imaging biomarker levels will be compared to the followings:Post-treatment metabolites from 13C-pyruvate DNP MRS after the first week of chemotherapyInterval change in tumor sizeADC values from diffusion weighted imaging (DWI), SUV values from 18F-FDG PET/CT before and after the first week of chemotherapyPre-treatment and interim follow up SUV values from 18F-FDG PET/CTPost-treatment outcome and to understand the change of metabolites before and after treatment and if possible, evaluate treatment outcome using the above imaging biomarkersAim 2:In Stage 2 of this study, the investigators aim to recruit lymphoma patients with proven relapse after treatment, to understand the changes of metabolites before and after treatment, to compare the metabolite changes with Stage 1 patients and to evaluate the ability of hyperpolarized 13C-labeled pyruvate from DNP MRS for detecting early treatment response in these patients.

Inclusion Criteria:Able to understand and provide signed informed consentWilling to receive 13C-pyruvate DNP MRS and return for post-treatment evaluation for the scheduled follow up imaging about 1 week after initiation of chemotherapy.Willing to receive therapy and follow-up as suggested by the tumor board and combined conference meeting in our institutionPresence of enlarged neck lymph nodes and/or spleen to serve as localized target for 3C-pyruvate DNP MRSThe exclusion criteria include:Contraindicated to MRI study: such as cardiac pacemaker, cochlear implantation, metallic object within eyeballPatients that refuse to, or has poor ability of understanding and comply study conditions, such as severe dementia or difficulty in mobilitExclusion Criteria:Contraindicated to MRI study: such as cardiac pacemaker, cochlear implantation, metallic object within eyeballPatients that refuse to, or has poor ability of understanding and comply study conditions, such as severe dementia or difficulty in mobilit