Clinical Characteristics of Patients Developing Chronic Dry Eye After Refractive Surgery

In recent years, many scholars have studied the ocular surface damage of patients with dry eye disease（DED）after FS-LASIK, but there has been a lack of comprehensive observation and research on the relationship and difference between dry eye （DE）patients with and without LASIK. Therefore, the purpose of this study was to investigate the characteristics of ocular surface and cytokines after FS-LASIK, and further explain the pathogenesis of chronic dry eyes after FS-LASIK.

Inclusion Criteria:Age 18years to 40 yearsMale or femaleDED patients based on Chinese Dry Eye Diagnosis Standard (2020) with or without FS-LASIKProvision of written informed consent.Exclusion Criteria:active ocular infection, ocular inflammation, active ocular allergy, severe blepharitis or obvious inflammation of the eyelid margin, which in the judgment of the investigator may interfere with the interpretation of the study results.Pregnant and lactating women, or those planning a pregnancy over the course of the studyUncontrolled systemic diseaseSuffer from diseases that may affect corneal nerves, such as keratoconus, trigeminal neuralgia, allergic conjunctivitis, etc.