Gut Microbiome and Blood Indices in Patients With AD and Their Spousal Caregivers

Spousal caregivers of Alzheimer's Dementia (AD) patients have an elevated risk of developing AD in the future. Past studies have shown the presence of serum indicators correlated with gut biome dysfunction in AD patients. We hypothesize that the same gut biome dysfunction may be present in spousal caregivers of AD patients.

Inclusion Criteria:patients with AD whose clinical dementia rating (CDR) is > 1Spouses of Patients in the above group OrHealthy adult unrelated to groups 1 and 2, with no history of dementia AndRegardless of the grouping, the prospective subject must be between 65 and 90 years oldExclusion Criteria:Familial Alzheimer's Disease (AD)Severe cardiovascular diseaseSevere respiratory system diseaseSevere liver diseaseSevere kidney diseaseSevere central nervous system diseasesHaving a lifespan of fewer than 3 monthsHistory of psychiatric illnessMajor neurological diseases other than ADCurrent use of corticosteroids, antibiotics, or bowel motility modification agentsAny history of Alcoholism or illicit drug dependencePrevious inclusion in this studyDifficulty with follow-up or poor complianceSevere hearing impairmentSevere vision impairment